![]() ![]() In my judgment we have been dosing up to 30 times the statin dose required for inflammation suppression. We should be using much lower, anti-inflammatory doses of statins. Now that we realize that atherosclerosis is an inflammatory problem secondary to a variety of triggers such as oxycholesterol, transfats, smoking, hidden infection, etc. the lowering of cholesterol is irrelevant. This is causing the overwhelming majority of statin drug side effects. To use statins at the high doses required to suppress cholesterol means one blocks the mevalonate pathway more and more completely, inevitably inhibiting CoQ10 and dolichols along with cholesterol. Graveline: For over 25 years we have been using cholesterol lowering doses of statins believing cholesterol to be the cause of atherosclerosis. Question: My question is one of confusion: I am not sure what your final word is on the effect of statins on your body.should they be taken to protect the heart, to protect against inflammation of some sort.as a last resort if your cholesterol remains above the 240 range.or should they never be taken at all.especially if you have had muscular problems with them in the past? You sometimes seem to write a column that has positive things to say about statins, and then you'll write one that is negative.what is the bottom line, sir?ĭr. Cholesterol appears to be irrelevant to the process of atherosclerosis.ģ. Cholesterol reduction has generally nothing to do with a statin's benefit. But in two cases, the condition appeared to be permanent on the basis of both testosterone level and symptoms.īecause of lowered levels of the substrate, cholesterol, I suspect other hormones such as progesterone and estrogen would show similar patterns of change but perhaps be somewhat less apparent clinically.Īs to the benefit of statins, that of decreasing cardiovascular ( CV ) risk, I doubt that cortisol contributes and am quite certain the anti-inflammatory benefit of statins is almost entirely a function of inhibition of nuclear factor kappa B. In one series of some 40 patients, testosterone values returned to normal within a few months after stopping the statin and these symptoms gradually diminished. Loss of libido and erectile dysfunction are two common complaints associated with statin use. This is true for vitamin D also, but only for testosterone has this been proven to occur. Graveline: Statins do tend to inhibit many of our hormones on the basis of cholesterol depletion. ![]() Since cortisol is derived from cholesterol, is it effectively depleted by statins? Following from this, is the possible reduction in cortisol a contributory factor to the beneficial effects of statins along with their depletion of the NF-kappaB and the subsequent inhibition of the cytokine stimulated inflammation?ĭr. As we know statins lower cholesterol and other important molecules. Question: The question I would like to ask relates to statins and their effect on the mevalonate pathway. To accept a test value higher than normal on the basis of drug company recommendations is reckless by my standards.Ģ. Yes the liver has tremendous healing and regenerative power but when it is elevated above normal it means the liver is being inflamed and not functioning normally. In my world you have a normal range and anything above that is abnormal. I am very concerned about some doctors placing the tolerable upper limit of normal for a liver function test as 5 times greater than normal or even 10 times greater than normal and suspect this was some ill advised recommendation from the drug companies to increase acceptability of elevated test value. For liver function tests, days and weeks will be required usually. Graveline: Generally speaking reactions of this kind take time to develop so it will not be a case of okay an hour ago but now abnormal. Question: When a person takes cholesterol lowering statin drugs, will the blood tests, such as liver function, rise over a period of time, or will it happen all at once and harm the organs?ĭr. Graveline is the author of Lipitor®, Thief of Memory Statin Drugs, Side Effects and The Misguided War on Cholesterol and The Statin Damage Crisis.ġ. Here are selected questions with answers from Dr. Newsletter readers were invited to submit some general questions on statin side effects. Dr. Duane Graveline - Questions and Answers ![]()
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